Xabi Alonso’s side were held to a 1-1 draw in their opening match against Al Hilal, with Gonzalo Garcia scoring early before Ruben Neves leveled from the penalty spot.
A win would put Real through to a knockout clash against Salzburg, while a defeat could effectively end their tournament run and shift focus back to domestic campaigns.
Pachuca, meanwhile, are in a must-win situation after a loss to Salzburg and risk elimination with another setback.
Adding to Real’s challenges, star forward Kylian Mbappe is likely to miss the match after being hospitalised with gastroenteritis in the lead-up to the game.
HOW TO WATCH REAL MADRID VS PACHUCA CLASH LIVE
Match: Real Madrid vs Pachuca
Venue: Bank of America Stadium, North Carolina
Date: June 22, Sunday
Start Time: 3pm ET
Where to Watch: DAZN